Product Name: Quinine

Synonyms: (R)-(6-Methoxyquinolin-4-yl)((1R,2R,4R,5S)-5-vinylquinuclidin-2-yl)Methanol;(1R)-(6-Methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)Methanol;(-)-QUININE FOR RESOLUTION OF RACEMATES;(R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol;Quinine, (R)-[(2S,4S,5R)-1-Aza-5-ethenylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol;Quinine Anhydrous, for Fluorescene;(8R,9S)-Quinidine-d3;(9S)-6'-Methoxycinchonan-9-ol-d3

CAS: 130-95-0
MF: C20H24N2O2
MW: 324.42
EINECS: 205-003-2

Product Categories: Alkaloids;Biochemistry;for Resolution of Acids;Optical Resolution;Quinoline Alkaloids;Synthetic Organic Chemistry;chiral;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;AlkaloidAsymmetric Synthesis;Chiral Resolving ReagentsChiral Catalysts, Ligands, and Reagents;Cinchona AlkaloidsVoltage-gated Ion Channels;Biochemicals Found in Plants;Chiral Resolution Reagents;Monovalent Ion Channels;Nutrition Research;Potassium Channel Modulators;Privileged Ligands and Complexes;Fluorescent;Quinoline;Inhibitors;QUALAQUIN;Heterocycles

Quinine Chemical Properties: 

Melting point: 173-175 °C(lit.)
alpha: -172 º (c=1, EtOH)
Boiling point: 462.75°C (rough estimate)
Density: 1.1294 (rough estimate)
Refractive index: 1.6250 (estimate)
Fp: >110°C (>230°F)
Storage temp.: Refrigerator
Solubility: H2O: soluble
pka: 8.52(at 25℃)
Form: Crystalline Powder
Color: White
PH: 9.0 (0.5g/l, H2O, 20℃)
PH Range: Blue I uorescence (3.0) to weak violet I uorescence (5.0);Weak violet I uorescence (9.5) to nonI uorescence (10.0)
Water Solubility: slightly soluble
HS Code: 29392110

Uses: Quinine is one of the oldest antimalarial drugs. It is capable of inhibiting the erythrocytic stage of a variety of Plasmodium, being able to control the malaria symptoms. It also has certain killing effect on the gametes of vivax malaria and quartan malaria. However, it has no effect on the exoerythrocytic stage. Its major advantage is not easy to produce drug resistance, possibly due to that quinine binds the plasmodium DNA in a different way from chloroquine, so having no cross-resistance and can be used for the treatment of the infection of anti-chloroquine strains (especially Plasmodium falciparum). In addition, quinine can also exciting the uterus, inhibit the myocardium and have antipyretic analgesic effect. In addition to medicinal application, in analytical chemistry it can be used as the detection agent of bismuth, platinum and other metal ions and also be used for the separation agent of racemic organic acid.

Uses: Quinines use as an antimalarial agent spans several hundred years, but it has been replaced in recent years by other substances such as chloroquine. Because some Plasmodium strains have developed resistance to several malaria medications, quinine use is being revived. About 60% of quinine production is used for medicinal purposes, and the drug is available by prescription. In addition to its use as an antimalarial agent, quinine medications are used to treat leg cramps, muscle cramps associated with kidney failure, hemorrhoids, heart palpitations, and as an analgesic. At higher concentrations it is toxic and causes a condition known as cinchonism. Conditions associated with cinchonism include dizziness, hearing loss, visual impairment, nausea, and vomiting.

Uses: Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal)

Uses: Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation.

Uses: antimalarial, skeletal muscle relaxant

Uses: Quinine is a flavorant naturally obtained from the cinchona tree. it is used as a bitter flavoring in beverages such as quinine water, tonic water, and bitter lemon. quinine sulfate and quinine hydrochloride are cleared for use as a flavor in carbonated beverages at levels less than 83 ppm.

Uses: Quinine occurs in the dried stems or rootbarks of cinchona (Cinchona ledgerianaMoens). It is used in the treatment of malaria.It is also used as an analgesic and antipyreticagent.

Pharmaceutical Applications: A quinolinemethanol from the bark of the Cinchona tree; the laevorotatory stereoisomer of quinidine. Formulated as the sulfate, bisulfate or ethylcarbonate for oral use and as the dihydrochloride for parenteral administration. The salts are highly soluble in water.

Clinical Use: Falciparum malaria (alone or in combination with tetracycline, doxycycline, clindamycin or pyrimethamine–sulfadoxine)
 

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